Šikimat dehidrogenaza
(Preusmjereno sa stranice DHS reduktaza)
Šikimat dehidrogenaza (EC 1.1.1.25, šikimatna dehidrogenaza, dehidrošikimatna reduktaza, šikimat oksidoreduktaza, šikimat:NADP+ oksidoreduktaza, 5-dehidrošikimat reduktaza, šikimat 5-dehidrogenaza, 5-dehidrošikimatna reduktaza, DHS reduktaza, šikimat:NADP+ 5-oksidoreduktaza, AroE) je enzim sa sistematskim imenom šikimat:NADP+ 3-oksidoreduktaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
| šikimat dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.25 | ||||||||
| CAS broj | 9026-87-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- šikimat + NADP+ 3-dehidrošikimat + NADPH + H+
NAD+ ne može da zameni NADP+. Kod viših organizma, ovaj enzim formira deo multienzimskog kompleksa sa EC 4.2.1.10, 3-dehidrohinat dehidratazom.
Reference uredi
- ↑ Balinsky, D. and Davies, D.D. (1961). „Aromatic biosynthesis in higher plants. 1. Preparation and properties of dehydroshikimic reductase”. Biochem. J. 80: 292-296. PMID 13686342.
- ↑ Mitsuhashi, S. and Davis, B.D. (1954). „Aromatic biosynthesis. XIII. Conversion of quinic acid to 5-dehydroquinic acid by quinic dehydrogenase”. Biochim. Biophys. Acta 15: 268-280. PMID 13208693.
- ↑ Yaniv, H. and Gilvarg, C. (1955). „Aromatic biosynthesis. XIV. 5-Dehydroshikimic reductase”. J. Biol. Chem. 213: 787-795. PMID 14367339.
- ↑ Chaudhuri, S. and Coggins, J.R. (1985). „The purification of shikimate dehydrogenase from Escherichia coli”. Biochem. J. 226: 217-223. PMID 3883995.
- ↑ Anton, I.A. and Coggins, J.R. (1988). „Sequencing and overexpression of the Escherichia coli aroE gene encoding shikimate dehydrogenase”. Biochem. J. 249: 319-326. PMID 3277621.
- ↑ Ye, S., Von Delft, F., Brooun, A., Knuth, M.W., Swanson, R.V. and McRee, D.E. (2003). „The crystal structure of shikimate dehydrogenase (AroE) reveals a unique NADPH binding mode”. J. Bacteriol. 185: 4144-4151. PMID 12837789.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.