3-dehidrohinat sintaza II
(Preusmjereno sa stranice DHQ synthase II)
3-dehidrohinat sintaza II (EC 1.4.1.24, DHQ sintaza II, MJ1249 (gen), aroB' (gen)) je enzim sa sistematskim imenom 2-amino-3,7-didezoksi-D-treo-hept-6-ulozonat:NAD+ oksidoreduktaza (deaminacija).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 3-dehidrohinat sintaza II | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.4.1.24 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2-amino-3,7-didezoksi-D-treo-hept-6-ulozonat + H2O + NAD+ 3-dehidrohinat + NH3 + NADH + H+
Ovaj enzim, koji je izolovan iz arheje Methanocaldococcus jannaschii, učestvuje u alternativnom putu biosinteze 3-dehidrohinata (DHQ), intermedijera kanoničkog puta biosinteze aromatičnih aminokiselina.
Reference uredi
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.