Diizopropilna fluorofosfataza
(Preusmjereno sa stranice DFPase)
Diizopropilna fluorofosfataza (EC 3.1.8.2, DFPaza, tabunaza, somanaza, organofosforno kiselinska anhidrolaza, organofosfat kiselinska anhidraza, OPA anhidraza, diizopropilfosfofluoridaza, dialkilfluorofosfataza, diizopropil fosforofluoridatna hidrolaza, izopropilfosforofluoridaza, diizopropilfluorofosfonatna dehalogenaza) je enzim sa sistematskim imenom diizopropil-fluorofosfat fluorohidrolaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
Diizopropilna fluorofosfataza | |||||||||
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Diizopropilna fluorofosfataza monomer, Loligo vulgaris | |||||||||
Identifikatori | |||||||||
EC broj | 3.1.8.2 | ||||||||
CAS broj | 9032-18-2 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- diizopropil fluorofosfat + H2O diizopropil fosfat + fluorid
Ovaj enzim deluje na fosforne anhidridne veze (poput fosfor-halida i fosfor-cijanida) u organofosfornim jedinjenjima (uključujući 'nervne gasove').
Reference uredi
- ↑ Augustinsson, K.-B. and Heimburger, G. (1954). „Enzymatic hydrolysis of organophosphorus compounds. I. Occurrence of enzymes hydrolysing dimethyl-amido-ethoxy-phosphoryl cyanide (Tabun)”. Acta Chem. Scand. 8: 753-761.
- ↑ Augustinsson, K.-B. and Heimburger, G. (1954). „Enzymatic hydrolysis of organophosphorus compounds. II. Analysis of reaction products in experiments with Tabun and some properties of blood plasma tabunase”. Acta Chem. Scand. 8: 762-767.
- ↑ Augustinsson, K.-B. and Heimburger, G. (1954). „Enzymatic hydrolysis of organophosphorus compounds. IV. Specificity studies”. Acta Chem. Scand. 8: 1533-1541.
- ↑ Cohen, J.A. and Warringa, M.G.P.J. (1957). „Purification and properties of dialkylfluorophosphatase”. Biochim. Biophys. Acta 26: 29-39. PMID 13479457.
- ↑ Mounter, L.A. (1960). „Enzymic hydrolysis of organophosphorus compounds”. u: Boyer, P.D., Lardy, H. and Myrbäck, K.. The Enzymes. 4 (2nd izd.). New York: Academic Press. str. 541-550.
- ↑ Reiner, E., Aldridge, W.N. and Hoskin, C.G., ur. (1989). Enzymes Hydrolysing Organophosphorus Compounds. Chichester, UK: Ellis Horwood. str. -.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Reiner, E., Aldridge, W.N. and Hoskin, C.G., ur. (1989). Enzymes Hydrolysing Organophosphorus Compounds. Chichester, UK: Ellis Horwood. str. -.
- Mounter, L.A. (1960). „Enzymic hydrolysis of organophosphorus compounds”. u: Boyer, P.D., Lardy, H. and Myrbäck, K.. The Enzymes. 4 (2nd izd.). New York: Academic Press. str. 541-550.