Poliprenol reduktaza
(Preusmjereno sa stranice DFG10 (gene name))
Poliprenol reduktaza (EC 1.3.1.94, SRD5A3 (gen), DFG10 (gen)) je enzim sa sistematskim imenom ditrans,policis-dolihol:NADP+ 2,3-oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Poliprenol reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.1.94 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- ditrans,policis-dolihol + NADP+ ditrans,policis-poliprenol + NADPH + H+
Reakcija se odvija u reverznom smeru uz redukciju terminalne dvostruke veze pored alkoholne grupe. Ovaj enzim je inicijalno izolovan iz ljudskog fetalnog moždanog tkiva. On je prisutan kod svih eukariota. U sisarskim ćelijama doliholi su predominanto 18-21 izoprenskih jedinica dugi.
Reference uredi
- ↑ Sagami, H., Kurisaki, A. and Ogura, K. (1993). „Formation of dolichol from dehydrodolichol is catalyzed by NADPH-dependent reductase localized in microsomes of rat liver”. J. Biol. Chem. 268: 10109-10113. PMID 8486680.
- ↑ Cantagrel, V., Lefeber, D.J., Ng, B.G., Guan, Z., Silhavy, J.L., Bielas, S.L., Lehle, L., Hombauer, H., Adamowicz, M., Swiezewska, E., De Brouwer, A.P., Blumel, P., Sykut-Cegielska, J., Houliston, S., Swistun, D., Ali, B.R., Dobyns, W.B., Babovic-Vuksanovic, D., van Bokhoven, H., Wevers, R.A., Raetz, C.R., Freeze, H.H., Morava, E., Al-Gazali, L. and Gleeson, J.G. (2010). „SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder”. Cell 142: 203-217. PMID 20637498.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.