Jodotirozin deiodinase
(Preusmjereno sa stranice DEHAL1)
Jodotirozin deiodinase (EC 1.22.1.1, jodotirozinska dehalogenaza 1, DEHAL1) je enzim sa sistematskim imenom NADP+:L-tirozin oksidoreduktaza (jodinacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Jodotirozin deiodinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.22.1.1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- L-tirozin + 2 NADP+ + 2 I- 3,5-dijodo-L-tirozin + 2 NADPH + 2 H+ (sveukupna reakcija)
- (1a) L-tirozin + NADP+ + I- 3-jodo-L-tirozin + NADPH + H+
- (1b) 3-jodo-L-tirozin + NADP+ + I- 3,5-dijodo-L-tirozin + NADPH + H+
Reakcija se odvija u smeru 3-dejodinacije. Ovaj enzim je transmembranski flavoprotein. Za njegovo dejstvo je neophodan FMN.
Reference uredi
- ↑ Rosenberg, I.N. (1970). „Purification of iodotyrosine deiodinase from bovine thyroid”. Metabolism 19: 785-798. PMID 4394169.
- ↑ Gnidehou, S., Caillou, B., Talbot, M., Ohayon, R., Kaniewski, J., Noel-Hudson, M.S., Morand, S., Agnangji, D., Sezan, A., Courtin, F., Virion, A. and Dupuy, C. (2004). „Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site”. FASEB J. 18: 1574-1576. PMID 15289438.
- ↑ Friedman, J.E., Watson, J.A., Jr., Lam, D.W. and Rokita, S.E. (2006). „Iodotyrosine deiodinase is the first mammalian member of the NADH oxidase/flavin reductase superfamily”. J. Biol. Chem. 281: 2812-2819. PMID 16316988.
- ↑ Thomas, S.R., McTamney, P.M., Adler, J.M., Laronde-Leblanc, N. and Rokita, S.E. (2009). „Crystal structure of iodotyrosine deiodinase, a novel flavoprotein responsible for iodide salvage in thyroid glands”. J. Biol. Chem. 284: 19659-19667. PMID 19436071.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.