D12-masna kiselina dehidrogenaza
D12-masna kiselina dehidrogenaza (EC 1.14.99.33, crepeninatna sintaza, linoleatna Delta12-masno kiselinska acetilenaza (desaturaza)) je enzim sa sistematskim imenom linoleat, vodonik-donor:kiseonik oksidoreduktaza (Delta12-unsaturacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju:
| D12-masna kiselina dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.99.33 | ||||||||
| CAS broj | 197025-40-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- linoleat + AH2 + O2 krepeninat + A + 2H2O
Ovaj enzim sadrži gvožđe nevezano za hem.
Reference uredi
- ↑ Banas, A., Bafor, M., Wiberg, E., Lenman, M., Staahl, U. and Stymne, S. (1997). „Biosynthesis of an acetylenic fatty acid in microsomal preparations from developing seeds Crepis alpina”. Physiol. Biochem. Mol. Biol. Plant. [Proc. Int. Symp. Plant Lipids] 12th: 57-59.
- ↑ Lee, M., Lenman, M., Banas, A., Bafor, M., Singh, S., Schweizer, M., Nilsson, R., Liljenberg, C., Dahlqvist, A., Gummeson, P.O., Sjodahl, S., Green, A. and Stymne, S. (1998). „Identification of non-heme di-iron proteins that catalyze triple bond and epoxy group formation”. Science 280: 915-918. PMID 9572738.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.