D-alanin—(R)-laktat ligaza
(Preusmjereno sa stranice D-alanine---(R)-lactate ligase)
D-alanin—(R)-laktat ligaza (EC 6.1.2.1, VanA, VanB, VanD) je enzim sa sistematskim imenom D-alanin:(R)-laktat ligaza (formira ADP).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| D-alanin—(R)-laktat ligaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.1.2.1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Produkt ovog enzim može da bude inkorporisan u peptidoglikan pentapeptid umesto u uobičajeni D-alanil-D-alanin dipeptid.
Reference uredi
- ↑ Bugg, T.D., Wright, G.D., Dutka-Malen, S., Arthur, M., Courvalin, P. and Walsh, C.T. (1991). „Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA”. Biochemistry 30: 10408-10415. PMID 1931965.
- ↑ Meziane-Cherif, D., Badet-Denisot, M.A., Evers, S., Courvalin, P. and Badet, B. (1994). „Purification and characterization of the VanB ligase associated with type B vancomycin resistance in Enterococcus faecalis V583”. FEBS Lett. 354: 140-142. PMID 7957913.
- ↑ Perichon, B., Reynolds, P. and Courvalin, P. (1997). „VanD-type glycopeptide-resistant Enterococcus faecium BM4339”. Antimicrob. Agents Chemother. 41: 2016-2018. PMID 9303405.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.