D-2-hidroksi-kiselina dehidrogenaza
D-2-hidroksi-kiselina dehidrogenaza (EC 1.1.99.6, D-2-hidroksi kiselinska dehidrogenaza, (R)-2-hidroksi-kiselina:(akceptor) 2-oksidoreduktaza) je enzim sa sistematskim imenom (R)-2-hidroksi-kiselina:akceptor 2-oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| D-2-hidroksi-kiselina dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.99.6 | ||||||||
| CAS broj | 9028-83-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- (R)-laktat + akceptor piruvat + redukovani akceptor
Ovaj enzim je cinkov flavoprotein (FAD). On deluje na više (R)-2-hidroksi kiselina.
Reference
uredi- ↑ Gregolin, C., Singer, T.P., Kearney, E.B. and Boeri, E. (1961). „The formation and enzymatic properties of the various lactic dehydrogenases of yeast”. Ann. N.Y. Acad. Sci. 94: 780-797. PMID 13901630.
- ↑ Nygaard, A.P. (1961). „D-(-)-Lactate cytochrome c reductase, a flavoprotein from yeast”. J. Biol. Chem. 236: 920-925. PMID 13729965.
- ↑ Tubbs, P.K. and Greville, G.D. (1959). „Dehydrogenation of D-lactate by a soluble enzyme from kidney mitochondria”. Biochim. Biophys. Acta 34: 290-291. PMID 13839714.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.