Cistein desumporaza
Cistein desumporaza (EC 2.8.1.7, IscS, NIFS, NifS, SufS, cisteinska desumporilaza) je enzim sa sistematskim imenom L-cistein:akceptor sumportransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Cistein desumporaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.8.1.7 | ||||||||
| CAS broj | 149371-08-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- L-cistein + akceptor L-alanin + S-sulfanil-akceptor (sveukupna reakcija)
- (1a) L-cistein + [enzim]-cistein L-alanin + [enzim]-S-sulfanilcistein
- (1b) [enzim]-S-sulfanilcistein + akceptor [enzim]-cistein + S-sulfanil-akceptor
Ovaj enzim je piridoksal-fosfatni protein.
Reference uredi
- ↑ Zheng, L.M., White, R.H., Cash, V.L., Jack, R.F. and Dean, D.R. (1993). „Cysteine desulfurase activity indicates a role for NIFS in metallocluster biosynthesis”. Proc. Natl. Acad. Sci. USA 90: 2754-2758. PMID 8464885.
- ↑ Mihara, H. and Esaki, N. (2002). „Bacterial cysteine desulfurases: Their function and mechanisms”. Appl. Microbiol. Biotechnol. 60: 12-23. PMID 12382038.
- ↑ Frazzon, J. and Dean, D.R. (2003). „Formation of iron-sulfur clusters in bacteria: An emerging field in bioinorganic chemistry”. Curr. Opin. Chem. Biol. 7: 166-173. PMID 12714048.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.