Cikloheksanon monooksigenaza
Cikloheksanon monooksigenaza (EC 1.14.13.22, cikloheksanonska 1,2-monooksigenaza, cikloheksanonska oksigenaza, cikloheksanon:NADPH:kiseonik oksidoreduktaza (6-hidroksilacija, 1,2-laktonizacija)) je enzim sa sistematskim imenom cikloheksanon,NADPH:kiseonik oksidoreduktaza (formira lakton).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Cikloheksanon monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.22 | ||||||||
| CAS broj | 52037-90-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- cikloheksanon + NADPH + H+ + O2 heksano-6-lakton + NADP+ + H2O
Ovaj enzim je flavoprotein (FAD).
Reference uredi
- ↑ Donoghue, N.A., Morris, D.B. and Trudgill, P.W. (1976). „The purification and properties of cyclohexanone oxygenase from Nocardia globerula CL1 and Acinetobacter NCIB 9871”. Eur. J. Biochem. 63: 175-192. PMID 1261545.
- ↑ Sheng, D., Ballou, D.P. and Massey, V. (2001). „Mechanistic studies of cyclohexanone monooxygenase: chemical properties of intermediates involved in catalysis”. Biochemistry 40: 11156-11167. PMID 11551214.
- ↑ Stewart, J.D. (1998). „Cyclohexanone monooxygenase: a useful reagent for asymmetric Baeyer-Villiger reactions”. Curr. Org. Chem. 2: 195-216.
- ↑ Chen, G., Kayser, M.M., Milhovilovic, M.D., Mrstik, M.E., Martinez, C.A. and Stewart, J.D. (1999). „Asymmetric oxidations at sulfur catalyzed by engineered strains that overexpress cyclohexanone monooxygenase”. New J. Chem. 23: 827-832.
- ↑ Ottolina, G., Bianchi, S., Belloni, B., Carrea, G. and Danieli, B. (1999). „First asymmetric oxidation of tertiary amines by cyclohexanone monooxygenase”. Tetrahedron Lett. 40: 8483-8486.
- ↑ Colonna, S., Gaggero, N., Carrea, G., Ottolina, G., Pasta, P. and Zambianchi, F. (2002). „First asymmetric epoxidation catalysed by cyclohexanone monooxygenase”. Tetrahedron Lett. 43: 1797-1799.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.