Holestarol-5,6-oksidna hidrolaza
(Preusmjereno sa stranice ChEH)
Holestarol-5,6-oksidna hidrolaza (EC 3.3.2.11, holestarol-epoksidna hidrolaza, ChEH) je enzim sa sistematskim imenom 5,6alfa-epoksi-5alfa-holestan-3beta-ol hidrolaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Holestarol-5,6-oksidna hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.3.2.11 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (1) 5,6alfa-epoksi-5alfa-holestan-3beta-ol + H2O 5alfa-holestan-3beta,5alfa,6beta-triol
- (2) 5,6beta-epoksi-5beta-holestan-3beta-ol + H2O 5alfa-holestan-3beta,5alfa,6beta-triol
Ovaj enzim deluje na širok opseg epoksida.
Reference uredi
- ↑ Levin, W., Michaud, D.P., Thomas, P.E. and Jerina, D.M. (1983). „Distinct rat hepatic microsomal epoxide hydrolases catalyze the hydration of cholesterol 5,6 α-oxide and certain xenobiotic alkene and arene oxides”. Arch. Biochem. Biophys. 220: 485-494. PMID 6401984.
- ↑ Oesch, F., Timms, C.W., Walker, C.H., Guenthner, T.M., Sparrow, A., Watabe, T. and Wolf, C.R. (1984). „Existence of multiple forms of microsomal epoxide hydrolases with radically different substrate specificities”. Carcinogenesis 5: 7-9. PMID 6690087.
- ↑ Sevanian, A. and McLeod, L.L. (1986). „Catalytic properties and inhibition of hepatic cholesterol-epoxide hydrolase”. J. Biol. Chem. 261: 54-59. PMID 3941086.
- ↑ Fretland, A.J. and Omiecinski, C.J. (2000). „Epoxide hydrolases: biochemistry and molecular biology”. Chem. Biol. Interact. 129: 41-59. PMID 11154734.
- ↑ Newman, J.W., Morisseau, C. and Hammock, B.D. (2005). „Epoxide hydrolases: their roles and interactions with lipid metabolism”. Prog. Lipid Res. 44: 1-51. PMID 15748653.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.