Geraniol 8-hidroksilaza
(Preusmjereno sa stranice CYP76B6)
Geraniol 8-hidroksilaza (EC 1.14.13.152, CYP76B6, G10H, CrG10H, SmG10H) je enzim sa sistematskim imenom geraniol,NADPH:kiseonik oksidoreduktaza (8-hidroksilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Geraniol 8-hidroksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.152 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- geraniol + NADPH + H+ + O2 (6E)-8-hidroksigeraniol + NADP+ + H2O
Ovaj enzim koristi citohrom P-450. On takođe deluje na nerol i citronelol.
Reference uredi
- ↑ Collu, G., Unver, N., Peltenburg-Looman, A.M., van der Heijden, R., Verpoorte, R. and Memelink, J. (2001). „Geraniol 10-hydroxylase, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis”. FEBS Lett. 508: 215-220. PMID 11718718.
- ↑ Wang, J., Liu, Y., Cai, Y., Zhang, F., Xia, G. and Xiang, F. (2010). „Cloning and functional analysis of geraniol 10-hydroxylase, a cytochrome P450 from Swertia mussotii Franch”. Biosci. Biotechnol. Biochem. 74: 1583-1590. PMID 20699579.
- ↑ Sung, P.H., Huang, F.C., Do, Y.Y. and Huang, P.L. (2011). „Functional expression of geraniol 10-hydroxylase reveals its dual function in the biosynthesis of terpenoid and phenylpropanoid”. J. Agric. Food Chem. 59: 4637-4643. PMID 21504162.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.