Granzim A
(Preusmjereno sa stranice CTLA3)
Granzim A (EC 3.4.21.78, CTLA3, HuTPS, proteaza 1 asociran sa T-ćelijom, citotoksična T limfocitna serinska proteaza, TSP-1, serinska proteinaza izvedena iz T-ćelija) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Granzim A | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.78 | ||||||||
| CAS broj | 143180-73-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Hidroliza proteina, uključujući fibronektin, tip IV kolagena i nukleolin. Preferentno odvajanje: -Arg-, -Lys- >> -Phe- u supstratima koji su mali molekuli
Ovaj enzim je prisutan u citotoksičnim T limfocitnim granulama.
Reference uredi
- ↑ Simon, M.M., Hoschützky, H., Fruth, U., Simon, H.-G. and Kramer, M.D. (1986). „Purification and characterization of a T cell specific serine proteinase (TSP-1) from cloned cytolytic T lymphocytes”. EMBO J. 5: 3267-3274. PMID 3545816.
- ↑ Gershenfeld, H.K., Hershberger, R.J., Shows, T.B. and Weissman, I.L. (1988). „Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine protease”. Proc. Natl. Acad. Sci. USA 85: 1184-1188. PMID 3257574.
- ↑ Odake, S., Kam, C.-M., Narasimhan, L., Poe, M., Blake, J.T., Krahenbuhl, O., Tschopp, J. and Powers, J.C. (1991). „Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins”. Biochemistry 30: 2217-2227. PMID 1998680.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.