Kofein sintaza
(Preusmjereno sa stranice CCS1)
Kofein sintaza (EC 2.1.1.160, dimetilksantinska metiltransferaza, 3N-metiltransferaza, DXMT, CCS1, S-adenozil-L-metionin:3,7-dimetilksantin 1-N-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:3,7-dimetilksantin N1-metiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Kofein sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.160 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (1) S-adenozil-L-metionin + 3,7-dimetilksantin S-adenozil-L-homocistein + 1,3,7-trimetilksantin
- (2) S-adenozil-L-metionin + 1,7-dimetilksantin S-adenozil-L-homocistein + 1,3,7-trimetilksantin
- (3) S-adenozil-L-metionin + 7-metilksantin S-adenozil-L-homocistein + 3,7-dimetilksantin
Paraksantin je najbolji supstrat ovog enzima.
Reference uredi
- ↑ Kato, M., Mizuno, K., Fujimura, T., Iwama, M., Irie, M., Crozier, A. and Ashihara, H. (1999). „Purification and characterization of caffeine synthase from tea leaves”. Plant Physiol. 120: 579-586. PMID 10364410.
- ↑ Mizuno, K., Okuda, A., Kato, M., Yoneyama, N., Tanaka, H., Ashihara, H. and Fujimura, T. (2003). „Isolation of a new dual-functional caffeine synthase gene encoding an enzyme for the conversion of 7-methylxanthine to caffeine from coffee (Coffea arabica L.)”. FEBS Lett. 534: 75-81. PMID 12527364.
- ↑ Uefuji, H., Ogita, S., Yamaguchi, Y., Koizumi, N. and Sano, H. (2003). „Molecular cloning and functional characterization of three distinct N-methyltransferases involved in the caffeine biosynthetic pathway in coffee plants”. Plant Physiol. 132: 372-380. PMID 12746542.
- ↑ Kato, M., Mizuno, K., Crozier, A., Fujimura, T. and Ashihara, H. (2000). „Caffeine synthase gene from tea leaves”. Nature 406: 956-957. PMID 10984041.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.