Ciklični-guanilat-specifična fosfodiestaraza
(Preusmjereno sa stranice C-di-GMP-specifična fosfodiesteraza)
Ciklični-guanilat-specifična fosfodiestaraza (EC 3.1.4.52, ciklična bis(3->5')diguanilatna fosfodiesteraza, c-di-GMP-specifična fosfodiesteraza, c-di-GMP fosfodiesteraza, fosfodiesteraza, fosfodiesteraza A1, PDEA1, VieA) je enzim sa sistematskim imenom ciklična bis(3->5')diguanilat 3-guanililhidrolaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Ciklični-guanilat-specifična fosfodiestaraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.4.52 | ||||||||
| CAS broj | 338732-46-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- ciklična di-3',5'-guanilat + H2O 5'-fosfoguanilil(3'->5')guanozin
Za dejstvo ovog enzima su neophodni Mg2+ ili Mn2+. Njega inhibiraju joni Ca2+ i Zn2+.
Reference uredi
- ↑ Chang, A.L., Tuckerman, J.R., Gonzalez, G., Mayer, R., Weinhouse, H., Volman, G., Amikam, D., Benziman, M. and Gilles-Gonzalez, M.A. (2001). „Phosphodiesterase A1, a regulator of cellulose synthesis in Acetobacter xylinum, is a heme-based sensor”. Biochemistry 40: 3420-3426. PMID 11297407.
- ↑ Christen, M., Christen, B., Folcher, M., Schauerte, A. and Jenal, U. (2005). „Identification and characterization of a cyclic di-GMP-specific phosphodiesterase and its allosteric control by GTP”. J. Biol. Chem. 280: 30829-30837. PMID 15994307.
- ↑ Schmidt, A.J., Ryjenkov, D.A. and Gomelsky, M. (2005). „The ubiquitous protein domain EAL is a cyclic diguanylate-specific phosphodiesterase: enzymatically active and inactive EAL domains”. J. Bacteriol. 187: 4774-4781. PMID 15995192.
- ↑ Tamayo, R., Tischler, A.D. and Camilli, A. (2005). „The EAL domain protein VieA is a cyclic diguanylate phosphodiesterase”. J. Biol. Chem. 280: 33324-33330. PMID 16081414.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.