Butirat-KoA ligaza
Butirat-KoA ligaza (EC 6.2.1.2, butiril-KoA sintetaza, masno kiselinska tiokinaza (lanca srednje dužine), acil-altivirajući enzim, masno kiselinska elongaza, masno kiselinski aktivirajući enzim, masna acil koenzim A sintetaza, sintetaza acil-KoA srednje dužine lanca, butiril-koenzim A sintetaza, L-(+)-3-hidroksibutiril KoA ligaza, sintetaza acil-KoA kratkog lanca) je enzim sa sistematskim imenom butanoat:KoA ligaza (formira AMP).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Butirat-KoA ligaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.2.1.2 | ||||||||
| CAS broj | 9080-51-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- ATP + karboksilat + KoA AMP + difosfat + acil-KoA
Ovaj enzim deluje na kiseline sa C4 do C11 dugim lancom.
Reference uredi
- ↑ Mahler, H.R., Wakil, S.J. and Bock, R.M. (1953). „Studies on fatty acid oxidation. I. Enzymatic activation of fatty acids”. J. Biol. Chem. 204: 453-468. PMID 13084616.
- ↑ Massaro, E.J. and Lennarz, W.J. (1965). „The partial purification and characterization of a bacterial fatty acyl coenzyme A synthetase”. Biochemistry 4: 85-90. PMID 14285249.
- ↑ Websterlt, J.R., Gerowin, L.D. and Rakita, L. (1965). „Purification and characteristics of a butyryl coenzyme A synthetase from bovine heart mitochondria”. J. Biol. Chem. 240: 29-33. PMID 14253428.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.