Bis(5'-nukleozil) tetrafosfataza (simetrična)
Bis(5'-nukleozil) tetrafosfataza (simetrična) (EC 3.6.1.41, diadenozintetrafosfataza (simetrična), dinukleozidtetrafosfataza (simetrična), simetrična diadenozin tetrafosfatna hidrolaza, adenozin tetrafosfatna fosfodiesteraza, Ap4A hidrolaza, bis(5'-adenozil) tetrafosfataza, diadenozin tetrafosfatna hidrolaza, diadenozin polifosfatna hidrolaza, diadenozin 5',5'''-P1,P4-tetrafosfataza, diadenozintetrafosfataza (simetrična), 1-P,4-P-bis(5'-nukleozil)-tetrafosfatna nukleozidbisfosfohidrolaza) je enzim sa sistematskim imenom P1,P4-bis(5'-nukleosil)-tetrafosfat nukleozidbisfosfohidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
Bis(5'-nukleozil) tetrafosfataza (simetrična) | |||||||||
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Identifikatori | |||||||||
EC broj | 3.6.1.41 | ||||||||
CAS broj | 85638-48-8 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- P1,P4-bis(5'-adenozil) tetrafosfat + H2O 2 ADP
Ovaj enzim takođe deluje na bis(5'-guanozil) tetrafosfat i bis(5'-adenozil) pentafosfat.
Reference
uredi- ↑ Barnes, L.D. and Culver, C.A. (1982). „Isolation and characterization of diadenosine 5′,5′′′-P1,P4-tetraphosphate pyrophosphohydrolase from Physarum polycephalum”. Biochemistry 21: 6123-6128. PMID 6295456.
- ↑ Guranowski, A., Jakubowski, H. and Holler, E. (1983). „Catabolism of diadenosine 5′,5′′′-P1,P4-tetraphosphate in procaryotes. Purification and properties of diadenosine 5′,5′′′-P1,P4-tetraphosphate (symmetrical) pyrophosphohydrolase from Escherichia coli K12”. J. Biol. Chem. 258: 14784-14789. PMID 6317672.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.