Birnovodonična kiselina a,c-diamidna sintaza (glutamin-hidrolizujuća)
Birnovodonična kiselina a,c-diamidna sintaza (glutamin-hidrolizujuća) (EC 6.3.5.9, CobB) je enzim sa sistematskim imenom kobirinovodonična kiselina:L-glutamin amido-ligaza (formira AMP).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Birnovodonična kiselina a,c-diamidna sintaza (glutamin-hidrolizujuća) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.3.5.9 | ||||||||
| CAS broj | 132053-22-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2 ATP + birnovodonična kiselina + 2 L-glutamin + 2H2O 2 ADP + 2 fosfat + birnovodonična kiselina a,c-diamid + 2 L-glutamat
Ova reakcija je deo aerobne biosinteze kobalamina.
Reference
uredi- ↑ Debussche, L., Thibaut, D., Cameron, B., Crouzet, J. and Blanche, F. (1990). „Purification and characterization of cobyrinic acid a,c-diamide synthase from Pseudomonas denitrificans”. J. Bacteriol. 172: 6239-6244. PMID 2172209.
- ↑ Warren, M.J., Raux, E., Schubert, H.L. and Escalante-Semerena, J.C. (2002). „The biosynthesis of adenosylcobalamin (vitamin B12)”. Nat. Prod. Rep. 19: 390-412. PMID 12195810.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.