Beta-kubebenska sintaza
Beta-kubebenska sintaza (EC 4.2.3.128, cop4, Mg25) je enzim sa sistematskim imenom (2E,6E)-farnezil-difosfat difosfat-lijaza (ciklizacija, formira beta-kubeben).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Beta-kubebenska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.3.128 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (2E,6E)-farnezil difosfat beta-kubeben + difosfat
Ovaj enzim je izolovan iz gljive Coprinus cinereus.
Reference uredi
- ↑ Lee, S. and Chappell, J. (2008). „Biochemical and genomic characterization of terpene synthases in Magnolia grandiflora”. Plant Physiol. 147: 1017-1033. PMID 18467455.
- ↑ Agger, S., Lopez-Gallego, F. and Schmidt-Dannert, C. (2009). „Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus”. Mol. Microbiol. 72: 1181-1195. PMID 19400802.
- ↑ Lopez-Gallego, F., Agger, S.A., Abate-Pella, D., Distefano, M.D. and Schmidt-Dannert, C. (2010). „Sesquiterpene synthases Cop4 and Cop6 from Coprinus cinereus: catalytic promiscuity and cyclization of farnesyl pyrophosphate geometric isomers”. Chembiochem. 11: 1093-1106. PMID 20419721.
- ↑ Lopez-Gallego, F., Wawrzyn, G.T. and Schmidt-Dannert, C. (2010). „Selectivity of fungal sesquiterpene synthases: role of the active site’s H-1α loop in catalysis”. Appl. Environ. Microbiol. 76: 7723-7733. PMID 20889795.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.