Benzoat 1,2-dioksigenaza
Benzoat 1,2-dioksigenaza (EC 1.14.12.10, benzoatna hidroksilaza, benzoatna hidroksilaza, benzoinska hidroksilaza, benzoatna dioksigenaza) je enzim sa sistematskim imenom benzoat,NADH:kiseonik oksidoreduktaza (1,2-hidroksilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Benzoat 1,2-dioksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.12.10 | ||||||||
| CAS broj | 9059-18-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- benzoat + NADH + H+ + O2 (1R,6S)-1,6-dihidroksicikloheksa-2,4-dien-1-karboksilat + NAD+
Ovaj enzim sadrži Fe2+.
Reference
uredi- ↑ Yamaguchi, M. and Fujisawa, H. (1978). „Characterization of NADH-cytochrome c reductase, a component of benzoate 1,2-dioxygenase system from Pseudomonas arvilla C-1”. J. Biol. Chem. 253: 8848-8853. PMID 214433.
- ↑ Yamaguchi, M. and Fujisawa, H. (1980). „Purification and characterization of an oxygenase component in benzoate 1,2-dioxygenase system from Pseudomonas arvilla C-1”. J. Biol. Chem. 255: 5058-5063. PMID 7372624.
- ↑ Yamaguchi, M. and Fujisawa, H. (1982). „Subunit structure of oxygenase component in benzoate-1,2-dioxygenase system from Pseudomonas arvilla C-1”. J. Biol. Chem. 257: 12497-12502. PMID 7130163.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.