Benzil reduktaza (formira (S)-benzoin)
Benzil reduktaza (formira (S)-benzoin) (EC 1.1.1.320, YueD) je enzim sa sistematskim imenom (S)-benzoin:NADP+ oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Benzil reduktaza (formira (S)-benzoin) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.320 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (S)-benzoin + NADP+ benzil + NADPH + H+
Ovaj enzim takođe redukuje 1-fenilpropan-1,2-dion. Enzim iz Bacillus cereus dodatno redukuje 1,4-naftohinon i 1-(4-metilfenil)-2-feniletan-1,2-dion sa visokom efikasnošću.
Reference uredi
- ↑ Maruyama, R., Nishizawa, M., Itoi, Y., Ito, S. and Inoue, M. (2001). „Isolation and expression of a Bacillus cereus gene encoding benzil reductase”. Biotechnol. Bioeng. 75: 630-633. PMID 11745140.
- ↑ Maruyama, R., Nishizawa, M., Itoi, Y., Ito, S. and Inoue, M. (2002). „The enzymes with benzil reductase activity conserved from bacteria to mammals”. J. Biotechnol. 94: 157-169. PMID 11796169.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.