3-Hidroksiindolin-2-on monooksigenaza
(Preusmjereno sa stranice BX4 (gen))
3-hidroksiindolin-2-on monooksigenaza (EC 1.14.13.139, BX4 (gen), CYP71C1 (gen)) je enzim sa sistematskim imenom 3-hidroksiindolin-2-on,NAD(P)H:kiseonik oksidoreduktaza (formira 2-hidroksi-2H-1,4-benzoksazin-3(4H)-on).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 3-hidroksiindolin-2-on monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.139 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 3-hidroksiindolin-2-on + NAD(P)H + H+ + O2 2-hidroksi-2H-1,4-benzoksazin-3(4H)-on + NAD(P)+ + H2O
Ovaj enzim učestvuje u biosintezi zaštitnih i alelofatskih benzoksazinoida kod pojedinih biljaka, i.e. Iz familije Poaceae (trave). On je član grupe citohrom P450 zavisnih monooksigenaza.
Reference
uredi- ↑ Glawischnig, E., Grun, S., Frey, M. and Gierl, A. (1999). „Cytochrome P450 monooxygenases of DIBOA biosynthesis: specificity and conservation among grasses”. Phytochemistry 50: 925-930. PMID 10385992.
- ↑ Frey, M., Chomet, P., Glawischnig, E., Stettner, C., Grün, S., Winklmair, A., Eisenreich, W., Bacher, A., Meeley, R.B., Briggs, S.P., Simcox, K. and Gierl, A. (1997). „Analysis of a chemical plant defense mechanism in grasses”. Science 277: 696-699. PMID 9235894.
- ↑ Spiteller, P., Glawischnig, E., Gierl, A. and Steglich, W. (2001). „Studies on the biosynthesis of 2-hydroxy-1,4-benzoxazin-3-one (HBOA) from 3-hydroxyindolin-2-one in Zea mays”. Phytochemistry 57: 373-376. PMID 11393516.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.