Indol-3-glicerol-fosfatna lijaza
(Preusmjereno sa stranice BX1)
Indol-3-glicerol-fosfatna lijaza (EC 4.1.2.8, triptofan sintaza alfa, TSA, indolglicerolfosfat aldolaza, indol glicerol fosfat hidrolaza, indol sintaza, indol-3-glicerolfosfat D-gliceraldehid-3-fosfat-lijaza, indol-3-glicerol fosfat lijaza, IGL, BX1, (1S,2R)-1-C-(indol-3-il)glicerol 3-fosfat D-gliceraldehid-3-fosfat-lijaza) je enzim sa sistematskim imenom (1S,2R)-1-C-(indol-3-il)glicerol-3-fosfat D-gliceraldehid-3-fosfat-lijaza (formira indol).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Indol-3-glicerol-fosfatna lijaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.1.2.8 | ||||||||
| CAS broj | 9014-52-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (1S,2R)-1-C-(indol-3-il)glicerol 3-fosfat indol + D-gliceraldehid 3-fosfat
Ovaj enzim učestvuje u odbrambenom mehanizmu protiv insekata i mikrobnih patogena u familiji trave, Graminae.
Reference uredi
- ↑ Yanofsky, C. (1956). „The enzymatic conversion of anthranilic acid to indole”. J. Biol. Chem. 223: 171-184. PMID 13376586.
- ↑ Frey, M., Chomet, P., Glawischnig, E., Stettner, C., Grün, S., Winklmair, A., Eisenreich, W., Bacher, A., Meeley, R.B., Briggs, S.P., Simcox, K. and Gierl, A. (1997). „Analysis of a chemical plant defense mechanism in grasses”. Science 277: 696-699. PMID 9235894.
- ↑ Frey, M., Stettner, C., Paré, P.W., Schmelz, E.A., Tumlinson, J.H. and Gierl, A. (2000). „An herbivore elicitor activates the gene for indole emission in maize”. Proc. Natl. Acad. Sci. USA 97: 14801-14806. PMID 11106389.
- ↑ Melanson, D., Chilton, M.D., Masters-Moore, D. and Chilton, W.S. (1997). „A deletion in an indole synthase gene is responsible for the DIMBOA-deficient phenotype of bxbx maize”. Proc. Natl. Acad. Sci. USA 94: 13345-13350. PMID 9371848.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.