Koštani morfogenetički protein 2
(Preusmjereno sa stranice BMP2A)
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Koštani morfogenetički protein 2 ili BMP-2 pripada TGF-β superfamiliji proteina.[1]
| Koštani morfogenetički protein 2 | |||||||||||
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 PDB prikaz baziran na 3bmp. | |||||||||||
| Dostupne strukture | |||||||||||
| 1ES7, 1REU, 1REW, 2GOO, 2H62, 2H64, 2QJ9, 2QJA, 2QJB, 3BK3, 3BMP | |||||||||||
| Identifikatori | |||||||||||
| Simboli | BMP2; BDA2; BMP2A | ||||||||||
| Vanjski ID | OMIM: 112261 MGI: 88177 HomoloGene: 926 GeneCards: BMP2 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 650 | 12156 | |||||||||
| Ensembl | ENSG00000125845 | ENSMUSG00000027358 | |||||||||
| UniProt | P12643 | P21274 | |||||||||
| Ref. Sekv. (iRNK) | NM_001200 | NM_007553 | |||||||||
| Ref. Sekv. (protein) | NP_001191 | NP_031579 | |||||||||
| Lokacija (UCSC) | Chr 20: 6.75 - 6.76 Mb | Chr 2: 133.55 - 133.56 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Funkcija uredi
BMP-2 poput drugih koštano morfogenetičkih proteina,[2] ima važnu ulogu u razviću kostiju i hrskavice. On učestvuje u hedgehog putu, TGF beta signalnom putu, i interakciji citokina sa citokinskim receptorom. On takođe učestvuje u diferencijaciji srčanih ćelija i epitelijalno mesenhimalnoj tranziciji.
BMP-2 i BMP-7 su osteoinduktivni BMP: demonstrirano je da oni potentno indukuju osteoblastnu diferencijaciju u brojnim tipovima ćelija.[3]
Interakcije uredi
Koštani morfogenetički protein 2 formira interakcije sa BMPR1A.[4][5][6][7]
Reference uredi
- ↑ Sampath TK, Coughlin JE, Whetstone RM, Banach D, Corbett C, Ridge RJ, Ozkaynak E, Oppermann H, Rueger DC (August 1990). „Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily”. J. Biol. Chem. 265 (22): 13198–205. PMID 2376592. Arhivirano iz originala na datum 2005-05-09. Pristupljeno 2014-06-29.
- ↑ Chen D, Zhao M, Mundy GR (December 2004). „Bone morphogenetic proteins”. Growth Factors 22 (4): 233–41. DOI:10.1080/08977190412331279890. PMID 15621726.
- ↑ Marie PJ, Debiais F, Haÿ E (2002). „Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling”. Histol. Histopathol. 17 (3): 877–85. PMID 12168799.
- ↑ Nickel J, Dreyer M K, Kirsch T, Sebald W (2001). „The crystal structure of the BMP-2:BMPR-IA complex and the generation of BMP-2 antagonists”. The Journal of bone and joint surgery. American volume 83-A Suppl 1 (Pt 1): S7–14. PMID 11263668.
- ↑ Kirsch T, Nickel J, Sebald W (February 2000). „Isolation of recombinant BMP receptor IA ectodomain and its 2:1 complex with BMP-2”. FEBS Lett. 468 (2-3): 215–9. DOI:10.1016/S0014-5793(00)01214-X. PMID 10692589.
- ↑ Kirsch T, Nickel J, Sebald W (July 2000). „BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II”. EMBO J. 19 (13): 3314–24. DOI:10.1093/emboj/19.13.3314. PMC 313944. PMID 10880444.
- ↑ Gilboa L, Nohe A, Geissendörfer T, Sebald W, Henis Y I, Knaus P (March 2000). „Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors”. Mol. Biol. Cell 11 (3): 1023–35. DOI:10.1091/mbc.11.3.1023. PMC 14828. PMID 10712517.
Literatura uredi
- Nickel J, Dreyer MK, Kirsch T, Sebald W (2001). „The crystal structure of the BMP-2:BMPR-IA complex and the generation of BMP-2 antagonists.”. The Journal of bone and joint surgery. American volume 83-A Suppl 1 (Pt 1): S7–14. PMID 11263668.
- Kawamura C, Kizaki M, Ikeda Y (2003). „Bone morphogenetic protein (BMP)-2 induces apoptosis in human myeloma cells.”. Leuk. Lymphoma 43 (3): 635–9. DOI:10.1080/10428190290012182. PMID 12002771.
- Marie PJ, Debiais F, Haÿ E (2003). „Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling.”. Histol. Histopathol. 17 (3): 877–85. PMID 12168799.