Bradikininski receptor B2

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Bradikininski receptor B₂ je G-protein spregnuti receptor bradikinina. Njega kodira BDKRB2 gen kod čoveka.

Bradikininski receptor B2
Identifikatori
Simboli	BDKRB2; B2R; BK-2; BK2; BKR2; BRB2; DKFZp686O088
Vanjski ID	OMIM: 113503 MGI: 102845 HomoloGene: 519 IUPHAR: B2 GeneCards: BDKRB2 Gene
Ontologija gena Molekularna funkcija • rodopsinu-slična receptorska aktivnost • aktivnost fosfoinozitid fosfolipaze C • receptorska aktivnost • aktivnost bradikininskog receptora Celularna komponenta • ćelijska membrana • integralno sa ćelijskom membranom Biološki proces • kontrakcija glatkih mišića • inflamatorni respons • signalni put tirozinske kinaze • signalni put G-protein spregnutog receptora • elevacija citosolne koncentracije jona kalcijuma • senzorna percepcija • cirkulacija
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	624	12062
Ensembl	ENSG00000168398	ENSMUSG00000021070
UniProt	P30411	P32299
RefSeq (mRNA)	NM_000623	NM_009747
RefSeq (protein)	NP_000614	NP_033877
Lokacija (UCSC)	Chr 14: 95.74 - 95.78 Mb	Chr 12: 105.96 - 105.99 Mb
PubMed pretraga	[1]	[2]

Mehanizam

B₂ receptor je G protein-spregnuti receptor. Pretpostavlja se da je spregnut sa G_q, dok G_i. G_q stimuliše fosfolipazu C i povišava koncentraciju Intracelularnog slobodnog kalcijuma i G_i inhibira adenilat ciklazu. Pored toga, receptor stimuliše puteve mitogenom-aktiviranih proteinskih kinaza. On je široko rasprostranjen i konstitutivno izražen u zdravim tkivima.

B₂ receptor formira kompleks sa angiotenzin konvertujućim enzimom (ACE), i stoga se smatra da učestvuje u razmeni informacija između renin-angiotenzinskog sistema (RAS) i kinin-kalikreinskog sistema (KKS). Heptapeptid angiotenzin 1-7 (A1-7) takođe pojačava dejstvo bradikinina na B₂ receptore.

Kalidin takođe dejstvuje kroz B₂ receptor.

Funkcija

Bradikinin je peptid sa 9 aminokiselina koji proizvodi mnogobrojne response kao što su vazodilatacija, edemi i spazam glatkih mišića.

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Bradikininski receptor

Literatura

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• Ariza AC, Bobadilla NA, Halhali A (2007). „[Endothelin 1 and angiotensin II in preeeclampsia]”. Rev. Invest. Clin. 59 (1): 48–56. PMID 17569300. 
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• Ma JX, Wang DZ, Ward DC, et al. (1995). „Structure and chromosomal localization of the gene (BDKRB2) encoding human bradykinin B2 receptor.”. Genomics 23 (2): 362–9. DOI:10.1006/geno.1994.1512. PMID 7835885. 
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• Efremov R, Truong MJ, Darcissac EC, et al. (1999). „Human chemokine receptors CCR5, CCR3 and CCR2B share common polarity motif in the first extracellular loop with other human G-protein coupled receptors implications for HIV-1 coreceptor function.”. Eur. J. Biochem. 263 (3): 746–56. DOI:10.1046/j.1432-1327.1999.00553.x. PMID 10469138. 
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