B-pirazolilalanin sintaza
B-pirazolilalanin sintaza (EC 2.5.1.51, beta-(1-pirazolil)alanin sintaza, beta-pirazolealanin sintaza, beta-pirazolilalanin sintaza (acetilserin), O3-acetil-L-serin acetat-lijaza (dodaje pirazol), BPA-sintaza, pirazolealanin sintaza, pirazolilalaninaza, 3-O-acetil-L-serin:pirazol 1-(2-amino-2-karboksietil)transferaza) je enzim sa sistematskim imenom O3-acetil-L-serin:pirazol 1-(2-amino-2-karboksietil)transferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| B-pirazolilalanin sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.51 | ||||||||
| CAS broj | 37290-81-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Ovaj enzim je visoko specifičan za acetilserin i pirazol.
Reference
uredi- ↑ Murakoshi, I., Ikegami, F., Hinuma, Y. and Hanma, Y. (1984). „Purification and characterization of β-(pyrazol-1-yl)-L-alanine synthase from Citrullus vulgaris”. Phytochemistry 23: 973-977.
- ↑ Murakoshi, I., Ikegami, F., Hinuma, Y. and Hanma, Y. (1984). „Purification and characterization of L-mimosine synthase from Leucaena leucocephala”. Phytochemistry 23: 1905-1908.
- ↑ Murakoshi, I., Kuramoto, H. and Haginiwa, J. (1972). „The enzymic synthesis of β-substituted alanines”. Phytochemistry 11: 177-182.
- ↑ Noji, M., Murakoshi, I. and Saito, K. (1993). „Evidence for identity of β-pyrazolealanine synthase with cysteine synthase in watermelon: formation of β-pyrazole-alanine by cloned cysteine synthase in vitro and in vivo”. Biochem. Biophys. Res. Commun. 197: 1111-1117. PMID 8280125.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.