B-N-acetilglukozaminil-glikopeptid b-1,4-galaktoziltransferaza
B-N-acetilglukozaminil-glikopeptid b-1,4-galaktoziltransferaza (EC 2.4.1.38, UDP-galaktoza---glikoprotein galaktoziltransferaza, glikoprotein 4-beta-galaktozil-transferaza, beta-N-acetil-beta1-4-galaktoziltransferaza, tiroid glikoprotein beta-galaktoziltransferaza, glikoprotein beta-galaktoziltransferaza, tiroid galaktoziltransferaza, uridin difosfogalaktoza-glikoprotein galaktoziltransferaza, beta-N-acetilglukozaminil-glikopeptid beta-1,4-galaktoziltransferaza, GalT, UDP-galaktoza:N-acetil-beta-D-glukozaminilglikopeptid beta-1,4-galaktoziltransferaza, UDP-galaktoza:N-acetil-beta-D-glukozaminilglikopeptid 4-beta-galaktoziltransferaza) je enzim sa sistematskim imenom UDP-alfa-D-galaktoza:N-acetil-beta-D-glukozaminilglikopeptid 4-beta-galaktoziltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| B-N-acetilglukozaminil-glikopeptid b-1,4-galaktoziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.38 | ||||||||
| CAS broj | 37237-43-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- UDP-alfa-D-galaktoza + N-acetil-beta-D-glukozaminilglikopeptid UDP + beta-D-galaktozil-(1->4)-N-acetil-beta-D-glukozaminilglikopeptid
Terminalni N-acetil-beta-D-glukozaminil ostataci u polisaharidima, glikoproteinima i glikopeptidima mogu da deluju kao akceptori.
Reference uredi
- ↑ Beyer, T.A., Sadler, J.E., Rearick, J.I., Paulson, J.C. and Hill, R.L. (1981). „Glucosyltransferases and their uses in assessing oligosaccharide structure and structure-function relationship”. Adv. Enzymol. 52: 23-175. PMID 6784450.
- ↑ Blanken, W.M., Hooghwinkel, G.J.M. and van den Eijnden, D.H. (1982). „Biosynthesis of blood-group I and i substances. Specificity of bovine colostrum β-N-acetyl-D-glucosaminide β1→4 galactosyltransferase”. Eur. J. Biochem. 127: 547-552. PMID 6816588.
- ↑ Blanken, W.M. and van den Eijnden, D.H. (1985). „Biosynthesis of terminal Gal α 1→3Gal β 1→4GlcNAc-R oligosaccharide sequences on glycoconjugates. Purification and acceptor specificity of a UDP-Gal:N-acetyllactosaminide α 1→3-galactosyltransferase from calf thymus”. J. Biol. Chem. 260: 12927-12934. PMID 3932335.
- ↑ Spiro, M.H. and Spiro, R.G. (1968). „Glycoprotein biosynthesis: studies on thyroglobulin. Thyroid galactosyltransferase”. J. Biol. Chem. 243: 6529-6537. PMID 5726898.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.