Azot-monoksid dioksigenaza
Azot-monoksid dioksigenaza (EC 1.14.12.17, azot-monoksidna dioksigenaza) je enzim sa sistematskim imenom azot suboksid,NAD(P)H:kiseonik oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Azot-monoksid dioksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Identifikatori | |||||||||
| EC broj | 1.14.12.17 | ||||||||
| CAS broj | 214466-78-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2 azot suboksid + 2 O2 + NAD(P)H 2 nitrat + NAD(P)+ + H+
Ovaj enzim je flavohemoglobin (FAD).
Reference
uredi- ↑ Gardner, P.R., Costantino, G. and Salzman, A.L. (1998). „Constitutive and adaptive detoxification of nitric oxide in Escherichia coli. Role of nitric-oxide dioxygenase in the protection of aconitase”. J. Biol. Chem. 273: 26528-26533. PMID 9756889.
- ↑ Gardner, P.R., Gardner, A.M., Martin, L.A. and Salzman, A.L. (1998). „Nitric oxide dioxygenase: an enzymic function for flavohemoglobin”. Proc. Natl. Acad. Sci. USA 95: 10378-10383. PMID 9724711.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.