Azobenzen reduktaza
Azobenzen reduktaza (EC 1.7.1.6, NC-reduktaza, NAD(P)H:1-(4'-sulfofenilazo)-2-naftolna oksidoreduktaza, oranž I azoreduktaza, azo reduktaza, azoreduktaza, nikotinamid adenin dinukleotid (fosfat) azoreduktaza, NADPH2-zavisna azoreduktaza, dimetilaminobenzenska reduktaza, p-dimetilaminoazobenzenska azoreduktaza, dibromopropilaminofenilazobenzoinska azoreduktaza, N,N-dimetil-4-fenilazoanilin azoreduktaza, p-aminoazobenzenska reduktaza, metil crvena azoreduktaza, NADPH2:4-(dimetilamino)azobenzenska oksidoreduktaza) je enzim sa sistematskim imenom N,N-dimetil-1,4-fenilendiamin, anilin:NADP+ oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Azobenzen reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.7.1.6 | ||||||||
| CAS broj | 9029-31-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- N,N-dimetil-1,4-fenilenediamin + anilin + 2 NADP+ 4-(dimetilamino)azobenzen + 2 NADPH + 2 H+
Reakcija se odvija u reverznom smeru.
Reference
uredi- ↑ Mueller, G.C. and Miller, J.A. (1949). „The reductive cleavage of 4-dimethylaminoazobenzene by rat liver: the intracellular distribution of the enzyme system and its requirements for triphosphopyridine nucleotide”. J. Biol. Chem. 180: 1125-1136.
- ↑ Suzuki, Y., Yoda, T., Ruhul, A. and Sugiura, W. (2001). „Molecular cloning and characterization of the gene coding for azoreductase from Bacillus sp. OY1-2 isolated from soil”. J. Biol. Chem. 276: 9059-9065. PMID 11134015.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.