Aureolizin
Aureolizin (EC 3.4.24.29, Staphylococcus aureus neutralna proteinaza, Staphylococcus aureus neutralna proteaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Aureolizin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.29 | ||||||||
| CAS broj | 39335-13-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Razlaganje lanca insulina B chain sa specifičnošću koja je slična sa termolizinom. Postoji preferencija za hidrofobne P1' ostatke. Aktivira se glutamilna endopeptidaza (EC 3.4.21.19) bakterije Staphylococcus aureus
Ovaj metaloenzim je prisutan u bakteriji S. Aureus.
Reference uredi
- ↑ Arvidson, S. (1973). „Studies on extracellular proteolytic enzymes from Staphylococcus aureus'. II. Isolation and characterization of an EDTA-sensitive protease”. Biochim. Biophys. Acta 302: 149-157. PMID 4632563.
- ↑ Saheb, S.A. (1976). „Purification et caractérisation d’une protéase extracellulaire de Staphylococcus aureus inhibée par l’E.D.T.A”. Biochimie 58: 793-804. PMID 823980.
- ↑ Drapeau, G.R. (1978). „Role of a metalloprotease in activation of the precursor of staphylococcal protease”. J. Bacteriol. 136: 607-613. PMID 711676.
- ↑ Potempa, J., Porwit-Bohr, Z. and Travis, J. (1989). „Stabilization vs. degradation of Staphylococcus aureus' metalloproteinase”. Biochim. Biophys. Acta 993: 301-304. PMID 2512988.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.