Arsenat reduktaza (azurin)
Arsenat reduktaza (azurin) (EC 1.20.9.1, arsenitna oksidaza) je enzim sa sistematskim imenom arsenit:azurin oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Arsenat reduktaza (azurin) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.20.9.1 | ||||||||
| CAS broj | 146907-46-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Ovaj enzim sadrži molibdopterinski centar koji se sastoji od dva molibdopterin guanozin dinukleotidna kofaktora vezana za molibden, [3Fe-4S] klustera i [2Fe-2S] klustera Riskijevog tipa.
Reference
uredi- ↑ Anderson, G.L., Williams, J. and Hille, R. (1992). „The purification and characterization of arsenite oxidase from Alcaligenes faecalis, a molybdenum-containing hydroxylase”. J. Biol. Chem. 267: 23674-23682. PMID 1331097.
- ↑ Ellis, P.J., Conrads, T., Hille, R. and Kuhn, P. (2001). „Crystal structure of the 100 kDa arsenite oxidase from Alcaligenes faecalis in two crystal forms at 1.64 Å and 2.03 Å”. Structure 9: 125-132. PMID 11250197.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.