Arogenat dehidrogenaza

Arogenat dehidrogenaza
Identifikatori
EC broj	1.3.1.43
CAS broj	64295-75-6
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Arogenat dehidrogenaza (EC 1.3.1.43, arogena dehidrogenaza (nespedifična), cikloheksadienilna dehidrogenaza, pretirozinska dehidrogenaza (nespecifična), L-arogenat:NAD+ oksidoreduktaza) je enzim sa sistematskim imenom L-arogenat:NAD⁺ oksidoreduktaza (dekarboksilacija).^[1]^[2]^[3]^[4]^[5] Ovaj enzim katalizuje sledeću hemijsku reakciju

L-arogenat + NAD⁺

\rightleftharpoons

L-tirozin + NADH + CO₂

Reference uredi

↑ Stenmark, S.L., Pierson, D.L., Jensen, R.A. and Glover, G.I. (1974). „Blue-green bacteria synthesise L-tyrosine by the pretyrosine pathway”. Nature 247: 290-292. PMID 4206476.
↑ Byng, G., Whitaker, R., Flick, C. and Jensen, R.A. (1981). „Enzymology of L-tyrosine biosynthesis in corn (Zea mays)”. Phytochemistry 20: 1289-1292.
↑ Mayer, E., Waldner-Sander, S., Keller, B., Keller, E. and Lingens, F. (1985). „Purification of arogenate dehydrogenase from Phenylobacterium immobile”. FEBS Lett. 179: 208-212. PMID 3967752.
↑ Lingens, F., Keller, E. and Keller, B. (1987). „Arogenate dehydrogenase from Phenylobacterium immobile”. Methods Enzymol. 142: 513-518.
↑ Zamir, L.O., Tiberio, R., Devor, K.A., Sauriol, F., Ahmad, S. and Jensen, R.A. (1988). „Structure of D-prephenyllactate. A carboxycyclohexadienyl metabolite from Neurospora crassa”. J. Biol. Chem. 263: 17284-17290. PMID 2972718.

Literatura uredi

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vidi još uredi

EC 1.3.1.12, prefenat dehidrogenaza
EC 1.3.1.78, arogenat dehidrogenaza (NADP⁺)
EC 1.3.1.79, arogenat dehidrogenaza (NAD(P)⁺)

Vanjske veze uredi

MeSH Arogenate+dehydrogenase

[1] Stenmark, S.L., Pierson, D.L., Jensen, R.A. and Glover, G.I. (1974). „Blue-green bacteria synthesise L-tyrosine by the pretyrosine pathway”. Nature 247: 290-292. PMID 4206476.

[2] Byng, G., Whitaker, R., Flick, C. and Jensen, R.A. (1981). „Enzymology of L-tyrosine biosynthesis in corn (Zea mays)”. Phytochemistry 20: 1289-1292.

[3] Mayer, E., Waldner-Sander, S., Keller, B., Keller, E. and Lingens, F. (1985). „Purification of arogenate dehydrogenase from Phenylobacterium immobile”. FEBS Lett. 179: 208-212. PMID 3967752.

[4] Lingens, F., Keller, E. and Keller, B. (1987). „Arogenate dehydrogenase from Phenylobacterium immobile”. Methods Enzymol. 142: 513-518.

[5] Zamir, L.O., Tiberio, R., Devor, K.A., Sauriol, F., Ahmad, S. and Jensen, R.A. (1988). „Structure of D-prephenyllactate. A carboxycyclohexadienyl metabolite from Neurospora crassa”. J. Biol. Chem. 263: 17284-17290. PMID 2972718.

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