Arahidonat 15-lipoksigenaza
Arahidonat 15-lipoksigenaza (EC 1.13.11.33, 15-lipoksigenaza, linoleinska kiselina omega6-lipoksigenaza, omega6 lipoksigenaza) je enzim sa sistematskim imenom arahidonat:kiseonik 15-oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Arahidonat 15-lipoksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.13.11.33 | ||||||||
| CAS broj | 82249-77-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- arahidonat + O2 (5Z,8Z,11Z,13E)-(15S)-15-hidroperoksiikosa-5,8,11,13-tetraenoat
Produkt se brzo redukuje do korespondirajućeg 15S-hidroksi jedinjenja.
Reference uredi
- ↑ Bryant, R.W., Bailey, J.M., Schewqe, T. and Rapoport, S.M. (1982). „Positional specificity of a reticulocyte lipoxygenase. Conversion of arachidonic acid to 15-S-hydroperoxy-eicosatetraenoic acid”. J. Biol. Chem. 257: 6050-6055. PMID 6804460.
- ↑ Narumiya, S. and Salmon, J.A. (1982). „Arachidonic acid-15-lipoxygenase from rabbit peritoneal polymorphonuclear leukocytes”. Methods Enzymol. 86: 45-48. PMID 6813644.
- ↑ Oliw, E.H. and Sprecher, H. (1989). „Metabolism of polyunsaturated fatty acids by an (n-6)-lipoxygenase associated with human ejaculates”. Biochim. Biophys. Acta 1002: 283-291. PMID 2496760.
- ↑ Shibata, D., Steczko, J., Dixon, F.E., Hermodson, M., Yasdanparast, R. and Axelrod, B. (1987). „Primary structure of soybean lipoxygenase-1”. J. Biol. Chem. 262: 10080-10085. PMID 3112136.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.