Antraniloil-KoA monooksigenaza
Antraniloil-KoA monooksigenaza (EC 1.14.13.40, antraniloil koenzim A reduktaza, 2-aminobenzoil-KoA monooksigenaza/reduktaza) je enzim sa sistematskim imenom 2-aminobenzoil-KoA,NAD(P)H:kiseonik oksidoreduktaza (dearomatizacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Antraniloil-KoA monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.40 | ||||||||
| CAS broj | 112692-57-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2-aminobenzoil-KoA + 2 NAD(P)H + 2 H+ + O2 2-amino-5-oksocikloheks-1-enkarboksil-KoA + H2O + 2 NAD(P)+
Ovaj enzim je flavoprotein (FAD). Nearomatični produkt je nestavilan i oslobađa se CO2 i NH3, čime se formira 1,4-cikloheksandion.
Reference
uredi- ↑ Buder, R. and Fuchs, G. (1989). „2-Aminobenzoyl-CoA monooxygenase/reductase, a novel type of flavoenzyme. Purification and some properties of the enzyme”. Eur. J. Biochem. 185: 629-635. PMID 2591379.
- ↑ Buder, R., Ziegler, K., Fuchs, G., Langkau, B. and Ghisla, S. (1989). „2-Aminobenzoyl-CoA monooxygenase/reductase, a novel type of flavoenzyme. Studies on the stoichiometry and the course of the reaction”. Eur. J. Biochem. 185: 637-643. PMID 2591380.
- ↑ Langkau, B., Ghisla, S., Buder, R., Ziegler, K. and Fuchs, G. (1990). „2-Aminobenzoyl-CoA monooxygenase/reductase, a novel type of flavoenzyme. Identification of the reaction products”. Eur. J. Biochem. 191: 365-371. PMID 2384085.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.