Antranilat 3-monooksigenaza (deaminacija)
Antranilat 3-monooksigenaza (deaminacija) (EC 1.14.13.35, antranilatna hidroksilaza, antranilatna 2,3-dioksigenaza (deaminacija), antranilatna hidroksilaza (deaminacija), antranilinska hidroksilaza, antranilatna 2,3-hidroksilaza (deaminacija)) je enzim sa sistematskim imenom antranilat,NADPH:kiseonik oksidoreduktaza (3-hidroksilacija, deaminacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Antranilat 3-monooksigenaza (deaminacija) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.35 | ||||||||
| CAS broj | 37256-68-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- antranilat + NADPH + H+ + O2 2,3-dihidroksibenzoat + NADP+ + NH3
Enzim iz Aspergillus niger sadrži gvožđe. Enzim iz kvasca Trichosporon cutaneum je flavoprotein (FAD).
Reference uredi
- ↑ Powlowski, J.B., Dagley, S., Massey, V. and Ballou, D.P. (1987). „Properties of anthranilate hydroxylase (deaminating), a flavoprotein from Trichosporon cutaneum”. J. Biol. Chem. 262: 69-74. PMID 3793735.
- ↑ Subramanian, V. and Vaidyanathan, C.S. (1984). „Anthranilate hydroxylase from Aspergillus niger: new type of NADPH-linked nonheme iron monooxygenase”. J. Bacteriol. 160: 651-655. PMID 6501219.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.