Aminokarboksimukonat-semialdehidna dekarboksilaza
Aminokarboksimukonat-semialdehidna dekarboksilaza (EC 4.1.1.45, pikolinsko kiselinska karboksilaza, pikolinsko kiselinska dekarboksilaza, alfa-amino-beta-karboksimukonat-epsilon-semialdehadna dekarboksilaza, alfa-amino-beta-karboksimukonat-epsilon-semialdehid beta-dekarboksilaza, 2-amino-3-(3-oksoprop-2-enil)but-2-enedioat karboksilijaza, 2-amino-3-(3-oksoprop-1-en-1-il)but-2-enedioat karboksilijaza) je enzim sa sistematskim imenom 2-amino-3-(3-oksoprop-1-en-1-il)but-2-enedioat karboksilijaza (formira 2-aminomukonat-semialdehid).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Aminokarboksimukonat-semialdehidna dekarboksilaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 4.1.1.45 | ||||||||
| CAS broj | 37289-47-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- 2-amino-3-(3-oksoprop-1-en-1-il)but-2-enedioat 2-aminomukonat semialdehid + CO2
Produkt se neenzimatski preuređuje do pikolinata.
Reference uredi
- ↑ Ichiyama, A., Nakamura, S., Kawai, H., Honjo, T., Nishizuka, Y., Hayaishi, O. and Senoh, S. (1965). „Studies on the metabolism of the benzene ring of tryptophan in mammalian tissues. II. Enzymic formation of α-aminomuconic acid from 3-hydroxyanthranilic acid”. J. Biol. Chem. 240: 740-749. PMID 14275130.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.