Amidofosforiboziltransferaza
Amidofosforiboziltransferaza (EC 2.4.2.14, fosforibozildifosfat 5-amidotransferaza, glutamin fosforibozildifosfat amidotransferaza, alfa-5-fosforibozil-1-pirofosfat amidotransferaza, 5'-fosforibozilpirofosfat amidotransferaza, 5-fosforibozil-1-pirofosfat amidotransferaza, 5-fosfororibozil-1-pirofosfat amidotransferaza, glutamin 5-fosforibozilpirofosfat amidotransferaza, glutamin ribozilpirofosfat 5-fosfat amidotransferaza, fosforiboza pirofosfat amidotransferaza, fosforibozil pirofosfat amidotransferaza, fosforibozilpirofosfat glutamil amidotransferaza, 5-fosforibozilamin:difosfat fosfo-alfa-D-riboziltransferaza (glutamatna amidacija)) je enzim sa sistematskim imenom 5-fosfo-beta-D-ribozilamin:difosfat fosfo-alfa-D-riboziltransferaza (glutamatna amidacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Amidofosforiboziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Amidofosforiboziltransferaza tetramer, E.Coli | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.4.2.14 | ||||||||
| CAS broj | 9031-82-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 5-fosfo-beta-D-ribozilamin + difosfat + L-glutamat L-glutamin + 5-fosfo-alfa-D-riboza 1-difosfat +H2O
Reference uredi
- ↑ Caskey, C.T., Ashton, D.M. and Wyngaarden, J.B. (1964). „The enzymology of feedback inhibition of glutamine phosphoribosylpyrophosphate amidotransferase by purine ribonucleotides”. J. Biol. Chem. 239: 2570-2579. PMID 14235537.
- ↑ Hartman, S.C. and Buchanan, J.M. (1958). „Biosynthesis of the purines. XXI. 5-Phosphoribosylpyrophosphate amidotransferase”. J. Biol. Chem. 233: 451-455. PMID 13563519.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.