Alkohol sulfotransferaza
Alkohol sulfotransferaza (EC 2.8.2.2, hidroksisteroidna sulfotransferaza, 3beta-hidroksi steroidna sulfotransferaza, Delta5-3beta-hidroksisteroidna sulfokinaza, 3-hidroksisteroidna sulfotransferaza, HST, 5alfa-androstenolna sulfotransferaza, holestarolna sulfotransferaza, dehidroepiandrosteronska sulfotransferaza, estrogenska sulfokinaza, estrogenska sulfotransferaza, steroid alkoholna sulfotransferaza, steroidna sulfokinaza, steroidna sulfotransferaza, sterolna sulfokinaza, sterolna sulfotransferaza, alkohol/hidroksisteroidna sulfotransferaza, 3beta-hidroksisteroidna sulfotransferaza) je enzim sa sistematskim imenom 3'-fosfoadenilil-sulfat:alkohol sulfotransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Alkohol sulfotransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.8.2.2 | ||||||||
| CAS broj | 9032-76-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 3'-fosfoadenilil sulfat + alkohol adenozin 3',5'-bisfosfat + alkil sulfat
Primarni i sekundarni alkoholi, uključujući alifatične alkohole, askorbinsku kiselinu, hloramfenikol, efedrin i hidroksisteroide, mogu da deluju kao akceptori.
Reference
uredi- ↑ Lyon, E.S. and Jakoby, W.B. (1980). „The identity of alcohol sulfotransferases with hydroxysteroid sulfotransferases”. Arch. Biochem. Biophys. 202: 474-481. PMID 6935986.
- ↑ Lyon, E.S., Marcus, C.J., Wang, J.-L. and Jakoby, W.B. (1981). „Hydroxysteroid sulfotransferase”. Methods Enzymol. 77: 206-213. PMID 6173569.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.