Alkohol dehidrogenaza (akceptor)
Alkohol dehidrogenaza (akceptor) (EC 1.1.99.8, primarno alkoholna dehidrogenaza, MDH, hinohemoproteinska alkoholna dehidrogenaza, hinoproteinska alkoholna dehidrogenaza, hinoprotein etanolna dehidrogenaza, alkohol:(akceptor) oksidoreduktaza) je enzim sa sistematskim imenom alkohol:akceptor oksidoreduktaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Alkohol dehidrogenaza (akceptor) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.99.8 | ||||||||
| CAS broj | 37205-43-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- primarni alkohol + akceptor aldehid + redukovani akceptor
Ovaj enzim je hinoprotein. On deluje na širok opseg primarnih alkohola, uključujući metanol (cf. EC 1.1.99.20, alkan-1-ol dehidrogenaza (akceptor)).
Reference uredi
- ↑ Ameyama, M. and Adachi, O. (1982). „Alcohol dehydrogenase from acetic acid bacteria, membrane-bound”. Methods Enzymol. 89: 450-457.
- ↑ Anthony, C. and Zatman, L.J. (1967). „The microbial oxidation of methanol. Purification and properties of the alcohol dehydrogenase of Pseudomonas sp. M27”. Biochem. J. 104: 953-959. PMID 6058112.
- ↑ Duine, J.A., Frank, J. and Van Zeeland, J.K. (1979). „Glucose dehydrogenase from Acinetobacter calcoaceticus: a 'quinoprotein'”. FEBS Lett. 108: 443-446. PMID 520586.
- ↑ Duine, J.A., Frank, J. and Verweil, P.E.J. (1980). „Structure and activity of the prosthetic group of methanol dehydrogenase”. Eur. J. Biochem. 108: 187-192. PMID 6250827.
- ↑ Salisbury, S.A., Forrest, H.S., Cruse, W.B.T. and Kennard, O. (1979). „A novel coenzyme from bacterial primary alcohol dehydrogenases”. Nature (Lond.) 280: 843-844. PMID 471057.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.