Aldos-2-ulozna dehidrataza
Aldos-2-ulozna dehidrataza (EC 4.2.1.110, piranozonska dehidrataza, AUDH, 1,5-anhidro-D-fruktoza dehidrataza (formira mikrotecin)) je enzim sa sistematskim imenom 1,5-anhidro-D-fruktoza hidrolijaza (formira mikrotecin).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Aldos-2-ulozna dehidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.110 | ||||||||
| CAS broj | 101920-80-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 1,5-anhidro-D-fruktoza 2-hidroksi-2-(hidroksimetil)-2H-piran-3(6H)-on + H2O (sveukupna reakcija)
- (1a) 1,5-anhidro-D-fruktoza 1,5-anhidro-4-dezoksi-D-glicero-heks-3-en-2-uloza + H2O
- (1b) 1,5-anhidro-4-dezoksi-D-glicero-heks-3-en-2-uloza 2-hidroksi-2-(hidroksimetil)-2H-piran-3(6H)-on
Ovaj enzim katalizuje dva koraka u reakcionom putu degradacije glikogena i skroba.
Reference uredi
- ↑ Yu, S. and Fiskesund, R. (2006). „The anhydrofructose pathway and its possible role in stress response and signaling”. Biochim. Biophys. Acta 1760: 1314-1322. PMID 16822618.
- ↑ Yu, S. (2005). „Enzymatic description of the anhydrofructose pathway of glycogen degradation. II. Gene identification and characterization of the reactions catalyzed by aldos-2-ulose dehydratase that converts 1,5-anhydro-D-fructose to microthecin with ascopyrone M as the intermediate”. Biochim. Biophys. Acta 1723: 63-73. PMID 15716041.
- ↑ Broberg, A., Kenne, L. and Pedersén, M. (1996). „Presence of microthecin in the red alga Gracilariopsis lemaneiformis and its formation from 1,5-anhydro-D-fructose”. Phytochemistry 41: 151-154.
- ↑ Gabriel, J., Volc, J., Sedmera, P., Daniel, G. and Kubátová, E. (1993). „Pyranosone dehydratase from the basidiomycete Phanerochaete chrysosporium: improved purification, and identification of 6-deoxy-D-glucosone and D-xylosone reaction products”. Arch. Microbiol. 160: 27-34. PMID 8352649.
- ↑ Yu, S., Refdahl, C. and Lundt, I. (2004). „Enzymatic description of the anhydrofructose pathway of glycogen degradation; I. Identification and purification of anhydrofructose dehydratase, ascopyrone tautomerase and α-1,4-glucan lyase in the fungus Anthracobia melaloma”. Biochim. Biophys. Acta 1672: 120-129. PMID 15110094.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.