Akvakobalamin reduktaza (NADPH)
Akvakobalamin reduktaza (NADPH) (EC 1.16.1.5, akvakobalamin (redukovani nikotinamid adenin dinukleotid fosfat) reduktaza, NADPH-vezana akvakobalaminska reduktaza, NADPH2:akvakob(III)alaminska oksidoreduktaza) je enzim sa sistematskim imenom kob(II)alamin:NADP+ oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Akvakobalamin reduktaza (NADPH) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.16.1.5 | ||||||||
| CAS broj | 110777-32-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2 kob(II)alamin + NADP+ 2 akvakob(III)alamin + NADPH + H+
Ovaj enzim je flavoprotein. On deluje na akvakob(III)alamin i hidroksikobalamin.
Reference uredi
- ↑ Watanabe, F., Oki, Y., Nakano, Y. and Kitaoka, S. (1987). „Purification and characterization of aquacobalamin reductase (NADPH) from Euglena gracilis”. J. Biol. Chem. 262: 11514-11518. PMID 3114247.
- ↑ Watanabe, F., Yamaji, R., Isegawa, Y., Yamamoto, T., Tamura, Y. and Nakano, Y. (1993). „Characterization of aquacobalamin reductase (NADPH) from Euglena gracilis”. Arch. Biochem. Biophys. 305: 421-427. PMID 8373179.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.