Akrocilindropepsin
Akrocilindropepsin (EC 3.4.23.28, Acrocylindrium proteinaza, Acrocylindrium kiselinska proteinaza) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Akrocilindropepsin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.23.28 | ||||||||
| CAS broj | 37288-84-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Postoji preferencija za hidrofobne ostatake u P1 i P1'. Dejstvo na B lanac insulina je generalno slično sa pepsinom A, ali dolazi i do razlaganja Leu6-Cys(SO3H), Glu21-Arg i Asn3-Gln, mada ne Gln4-His
Ovaj enzim je prisutan u glivi Acrocylindrium sp.
Reference uredi
- ↑ Uchino, F., Kurono, Y. and Doi, S. (1967). „Purification and some properties of crystalline acid protease from Acrocylindrium sp”. Agric. Biol. Chem. 31: 428-434.
- ↑ Ichihara, S. and Uchino, F. (1975). „The specificity of acid proteinase from Acrocylindrium”. Agric. Biol. Chem. 39: 423-428.
- ↑ Takahashi, K. and Chang, W.-J. (1976). „The structure and function of acid proteases. V. Comparative studies on the specific inhibition of acid proteases by diazoacetyl-DL-norleucine methyl ester, 1,2-epoxy-3-(p-nitrophenoxy)propane and pepstatin”. J. Biochem. (Tokyo) 80: 497-506. PMID 10290.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.