Acil-KoA oksidaza
Acil-KoA oksidaza (EC 1.3.3.6, masni acil-KoA oksidaza, acil koenzim A oksidaza, masni acil-koenzim A oksidaza) je enzim sa sistematskim imenom acil-KoA:kiseonik 2-oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju:
| Acil-KoA oksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.3.6 | ||||||||
| CAS broj | 61116-22-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- acil-KoA + O2 trans-2,3-dehidroacil-KoA +H2O2
Ovaj enzim je flavoprotein (FAD). On deluje na KoA derivate masnih kiselina sa lancem duhim od 8 do 18 ugljenika.
Reference
uredi- ↑ Kawaguchi, A., Tsubotani, S., Seyama, Y., Yamakawa, T., Osumi, T., Hashimoto, T., Kikuchi, T., Ando, M. and Okuda, S. (1980). „Stereochemistry of dehydrogenation catalyzed by acyl-CoA oxidase”. J. Biochem. (Tokyo) 88: 1481-1486. PMID 7462191.
- ↑ Osumi, T., Hashimoto, T. and Ui, N. (1980). „Purification and properties of acyl-CoA oxidase from rat liver”. J. Biochem. (Tokyo) 87: 1735-1746. PMID 7400120.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.