Acetolaktatna dekarboksilaza
(Preusmjereno sa stranice Acetolaktat dekarboksilaza)
Acetolaktatna dekarboksilaza (EC 4.1.1.5, alfa-acetolaktatna dekarboksilaza, (S)-2-hidroksi-2-metil-3-oksobutanoat karboksi-lijaza, (S)-2-hidroksi-2-metil-3-oksobutanoat karboksi-lijaza (formira (R)-2-acetoin), (S)-2-hidroksi-2-metil-3-oksobutanoat karboksi-lijaza (formira (3R)-3-hidroksibutan-2-on)) je enzim sa sistematskim imenom (2S)-2-hidroksi-2-metil-3-oksobutanoat karboksi-lijaza (formira (3R)-3-hidroksibutan-2-on).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Acetolaktatna dekarboksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.1.1.5 | ||||||||
| CAS broj | 2602394 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (2S)-2-hidroksi-2-metil-3-oksobutanoat (3R)-3-hidroksibutan-2-on + CO2
Reference
uredi- ↑ Hill, R.K., Sawada, S. and Arfin, S.M. (1979). „Stereochemistry of valine and isoleucine biosynthesis. IV. Synthesis, configuration, and enzymatic specificity of α-acetolactate and α-aceto-α-hydroxybutyrate”. Bioorg. Chem. 8: 175-189.
- ↑ Størmer, F.C. (1967). „Isolation of crystalline pH 6 acetolactate-forming enzyme from Aerobacter aerogenes”. J. Biol. Chem. 242: 1756-1759. PMID 6024768.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.