Acetilenkarboksilatna hidrataza
Acetilenkarboksilatna hidrataza (EC 4.2.1.27, acetilenmonokarboksilatna hidrataza, alkinoatna hidrataza, acetilenmonokarboksilatna hidraza, acetilenmonokarboksilna kiselinska hidraza, malonat-semialdehidna dehidrataza, 3-oksopropanoat hidrolijaza) je enzim sa sistematskim imenom 3-oksopropanoat hidrolijaza (formira propinoat).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Acetilenkarboksilatna hidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.27 | ||||||||
| CAS broj | 9024-26-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 3-oksopropanoat propinoat + H2O
Reakcija je efektivno ireverzibilna.
Reference uredi
- ↑ Van den Tweel, W.J.J. and De Bont, J.A.M. (1985). „Metabolism of 3-butyn-1-ol by Pseudomonas BB1”. J. Gen. Microbiol. 131: 3155-3162.
- ↑ Yamada, E.W. and Jakoby, W.B. (1959). „Enzymatic utilization of acetylenic compounds. II. Acetylenemonocarboxylic acid hydrase”. J. Biol. Chem. 234: 941-945. PMID 13654296.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.