Acetilajmalinska estaraza
Acetilajmalinska estaraza (EC 3.1.1.80, AAE, 2beta(R)-17-O-acetilajmalan:acetilesteraza, acetilajmalanska esteraza) je enzim sa sistematskim imenom 17-O-acetilajmalin O-acetilhidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Acetilajmalinska estaraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.1.80 | ||||||||
| CAS broj | 110183-46-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (1) 17-O-acetilajmaline + H2O ajmalin + acetat
- (2) 17-O-acetilnorajmaline + H2O norajmaline + acetat
Ovaj biljni enzim je odgovoran za zadnji stupanj biosinteze indolnog alkaloida ajmalina.
Reference uredi
- ↑ Polz, L., Schübel, H. and Stöckigt, J. (1987). „Characterization of 2β(R)-17-O-acetylajmalan:acetylesterase—a specific enzyme involved in the biosynthesis of the Rauwolfia alkaloid ajmaline”. Z. Naturforsch. [C] 42: 333-342. PMID 2955586.
- ↑ Ruppert, M., Woll, J., Giritch, A., Genady, E., Ma, X. and Stöckigt, J. (2005). „Functional expression of an ajmaline pathway-specific esterase from Rauvolfia in a novel plant-virus expression system”. Planta 222: 888-898. PMID 16133216.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.