Abietadienska sintaza
Abietadienska sintaza (EC 4.2.3.18, kopalil-difosfat difosfat-lijaza (ciklizacija)) je enzim sa sistematskim imenom (+)-kopalil-difosfat difosfat-lijaza (ciklizacija, formira abieta-7,13-dien).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Abietadienska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.3.18 | ||||||||
| CAS broj | 157972-08-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (+)-kopalil difosfat abieta-7,13-dien + difosfat
Ovaj enzim učestvuje u biosintezi abietadiena.
Reference
uredi- ↑ Peters, R.J., Flory, J.E., Jetter, R., Ravn, M.M., Lee, H.J., Coates, R.M. and Croteau, R.B. (2000). „A'bietadiene synthase from grand fir (Abies grandis): characterization and mechanism of action of the "pseudomature" recombinant enzyme”. Biochemistry 39: 15592-15602. PMID 11112547.
- ↑ Peters, R.J., Ravn, M.M., Coates, R.M. and Croteau, R.B. (2001). „Bifunctional abietadiene synthase: free diffusive transfer of the (+)-copalyl diphosphate intermediate between two distinct active sites”. J. Am. Chem. Soc. 123: 8974-8978. PMID 11552804.
- ↑ Peters, R.J. and Croteau, R.B. (2002). „Abietadiene synthase catalysis: mutational analysis of a prenyl diphosphate ionization-initiated cyclization and rearrangement”. Proc. Natl. Acad. Sci. USA 99: 580-584. PMID 11805316.
- ↑ Peters, R.J. and Croteau, R.B. (2002). „Abietadiene synthase catalysis: conserved residues involved in protonation-initiated cyclization of geranylgeranyl diphosphate to (+)-copalyl diphosphate”. Biochemistry 41: 1836-1842. PMID 11827528.
- ↑ Ravn, M.M., Peters, R.J., Coates, R.M. and Croteau, R. (2002). „Mechanism of abietadiene synthase catalysis: stereochemistry and stabilization of the cryptic pimarenyl carbocation intermediates”. J. Am. Chem. Soc. 124: 6998-7006. PMID 12059223.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.