Adenilil-sulfat kinaza
(Preusmjereno sa stranice APS kinase)
Adenilil-sulfat kinaza (EC 2.7.1.25, adenililsulfatna kinaza (fosforilacija), 5'-fosfoadenozin sulfatna kinaza, adenozin 5'-fosfosulfatna kinaza, adenozin fosfosulfatna kinaza, adenozinska fosfosulfokinaza, adenozin-5'-fosfosulfat-3'-fosfokinaza, APS kinaza) je enzim sa sistematskim imenom ATP:adenilil-sulfat 3'-fosfotransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Adenilil-sulfat kinaza | |||||||||
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| Adenilil-sulfat kinaza homohexamer, Thiobacillus denitrificans | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.7.1.25 | ||||||||
| CAS broj | 9012-38-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- ATP + adenilil sulfat ADP + 3'-fosfoadenilil sulfat
Ljudski sistem fosfoadenozin-fosfosulfatne sintaze (PAPSS) je bifunkcionalani enzim (fuzioni produkt kve katalitičke aktivnosti).
Reference uredi
- ↑ Bandurski, R.S., Wilson, L.G., Squires, C.L. (1956). „T'he mechanism of "active sulfate" formation”. J. Am. Chem. Soc. 78: 6408-6409.
- ↑ Robbins, P.W., Lipmann, F. (1957). „Isolation and identification of active sulfate”. J. Biol. Chem. 229: 837-851. PMID 13502346.
- ↑ Venkatachalam, K.V., Akita, H., Strott, C. (1998). „Molecular cloning, expression and characterization of human bifunctional 3′-phosphoadenosine-5′-phosphosulfate synthase and its functional domains”. J. Biol. Chem. 273: 19311-19320. PMID 9668121.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.