Defosfo-(reduktaza kinaza) kinaza
(Preusmjereno sa stranice AMP-activated protein kinase kinase)
Defosfo-(reduktaza kinaza) kinaza (EC 2.7.11.3, AMP-activirana kinaza, AMP-activirana proteinska kinaza kinaza, hidroksimetilglutaril koenzim A reduktaza kinaza kinaza, hidroksimetilglutaril koenzim A reduktaza kinaza kinaza (fosforilacija), reduktazna kinaza, reduktazna kinaza kinaza, STK30) je enzim sa sistematskim imenom ATP:defosfo(hidroksimetilglutaril-KoA reduktaza (NADPH)) kinaza} fosfotransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Defosfo-(reduktaza kinaza) kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.11.3 | ||||||||
| CAS broj | 72060-33-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- ATP + defosfo[hidroksimetilglutaril-KoA reduktaza (NADPH)] kinaza} ADP + {[hidroksimetilglutaril-KoA reduktaza (NADPH)] kinaza}
Ovaj enzim se aktivira AMP-om i specifičan je za svoj supstrat.
Reference
uredi- ↑ Beg, Z.H., Stonik, J.A. and Brewer, H.B., Jr. (1979). „Characterization and regulation of reductase kinase, a protein kinase that modulates the enzymic activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase”. Proc. Natl. Acad. Sci. USA 76: 4375-4379. PMID 291971.
- ↑ Ingebritsen, T.S., Lee, H.-S., Parker, R.A. and Gibson, D.M. (1978). „Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme A reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation”. Biochem. Biophys. Res. Commun. 81: 1268-1277. PMID 666819.
- ↑ Beg, Z.H., Stonik, J.A. and Brewer, H.B., Jr. (1985). „Phosphorylation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and modulation of its enzymic activity by calcium-activated and phospholipid-dependent protein kinase”. J. Biol. Chem. 260: 1682-1687. PMID 3155737.
- ↑ Clarke, P.R. and Hardie, D.G. (1990). „Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver”. EMBO J. 9: 2439-2446. PMID 2369897.
- ↑ Sato, R., Goldstein, J.L. and Brown, M.S. (1993). „Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion”. Proc. Natl. Acad. Sci. USA 90: 9261-9265. PMID 8415689.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.