Adenilil-sulfat reduktaza (glutation)
(Preusmjereno sa stranice AMP,sulfit:glutation-disulfid oksidoreduktaza (formira adenozin-5'-fosfosulfat))
Adenilil-sulfat reduktaza (glutation) (EC 1.8.4.9, 5'-adenililsulfat reduktaza, AMP,sulfit:oksidovani-glutation oksidoreduktaza (formira adenozin-5'-fosfosulfat), biljni tip 5'-adenililsulfatne reduktaze) je enzim sa sistematskim imenom AMP,sulfit:glutation-disulfid oksidoreduktaza (formira adenozin-5'-fosfosulfat).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju:
| Adenilil-sulfat reduktaza (glutation) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.8.4.9 | ||||||||
| CAS broj | 355840-27-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Ovaj enzim se razlikuje od EC 1.8.99.2, adenilil-sulfatne reduktaze, po tome što koristi glutation kao reduktant. Glutation može da bude zamenjen gama-glutamilcisteinom ili ditiotreitolom.
Reference
uredi- ↑ Gutierrez-Marcos, J.F., Roberts, M.A., Campbell, E.I. and Wray, J.L. (1996). „Three members of a novel small gene-family from Arabidopsis thaliana able to complement functionally an Escherichia coli mutant defective in PAPS reductase activity encode proteins with a thioredoxin-like domain and 'APS reductase' activity”. Proc. Natl. Acad. Sci. USA 93: 13377-13382. PMID 8917599.
- ↑ Setya, A., Murillo, M. and Leustek, T. (1996). „Sulfate reduction in higher plants: Molecular evidence for a novel 5-adenylylphosphosulfate (APS) reductase”. Proc. Natl. Acad. Sci. USA 93: 13383-13388. PMID 8917600.
- ↑ Bick, J.A., Aslund, F., Cen, Y. and Leustek, T. (1998). „Glutaredoxin function for the carboxyl-terminal domain of the plant-type 5′-adenylylsulfate reductase”. Proc. Natl. Acad. Sci. USA 95: 8404-8409. PMID 9653199.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.